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‘The Second Best Hospital in the Galaxy’ Official Trailer Samples a Cutting Sci-Fi Comedy

The Second Best Hospital in The Galaxy

Today, Prime Video released the trailer for the upcoming adult animated series The Second Best Hospital in the Galaxy and announced the guest stars who will be scrubbing in for Season 1. Set to the boppy “Oh!” by The Linda Lindas, the preview gives audiences a first glimpse at the wild life forms and out-of-this-world challenges facing the crack medical team at this sci-fi comedy clinic.

From Emmy Award-winning creator Cirocco Dunlap and Maya Rudolph, Danielle Renfrew Behrens and Natasha Lyonne’s Animal Pictures, The Second Best Hospital in the Galaxy is produced by Amazon MGM Studios, with animation by Titmouse Studios, the series, which has a two-season order, will premiere exclusively on Prime Video in more than 240 countries and territories worldwide on February 23.

Tracee Ellis Ross (American Fiction, Black-ish),Bowen Yang (Saturday Night Live, Fire Island), Abbi Jacobson (Broad City), Jay Ellis (Top Gun: Maverick, Insecure), Andrew Dismukes (Saturday Night Live), Lennon Parham (Minx), Gary Anthony Williams (Night Court) and John Waters (Hairspray) will all make appearances in the eight-episode debut season.

Fans are also in store for a family reunion this season, when Kieran Culkin, who voices Plowp, is joined by his real-life brothers, Macaulay Culkin, Rory Culkin, Christian Culkin and Shane Culkin.

The guest stars join previously announced series regulars Maya Rudolph, Natasha Lyonne, Keke Palmer, Stephanie Hsu, Kieran Culkin and Sam Smith.

Synopsis: The Second Best Hospital in the Galaxy follows Dr. Sleech and Dr. Klak — aliens, best friends and intergalactically renowned surgeons — as they tackle anxiety-eating parasites, illegal time loops and deep-space STIs.

In Season 1, doctors Sleech and Klak take on a highly dangerous and potentially groundbreaking case and, in doing so, put existence itself in jeopardy. Although considering their dismal personal lives, oblivion might be an improvement.

In a creator’s statement, Dunlop described her show: “Like a traditional procedural, every episode introduces a new sci-fi illness (e.g. run-of-the-mill diseases like getting stuck in a time loop, or an STI that turns you into the last person you slept with). While this show is funny and absurd, a sci-fi hospital is also a natural place to explore deeper emotional themes like mental illness, chosen & rejected family, and — of course — how to find clothes that fit when you turn into the last person you slept with.

“Mental illness, untimely death, and short legs run in my family, and you’ll find all of these at play throughout the first season. Additionally, you’ll watch extremely driven characters who are passionate about their careers as they try (and fail, and try, and fail) to love each other. I hope they offer some warmth, comfort and laughter in the face of life’s greatest joke: the ever-present nearness of death.”

Dunlap also serves as showrunner, writer and executive producer along with executive producers Rudolph, Behrens and Lyonne for Animal Pictures. Shauna McGarry, Shannon Prynoski, Chris Prynoski, Antonio Canobbio and Ben Kalina from Titmouse executive produce. Artist and animator Robin Eisenberg is co-producer and production designer.

Read more about The Second Best Hospital in the Galaxy in the March ’24 issue of Animation Magazine (No. 388), available soon!

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